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Can kratom cause high blood pressure

November 25, 2023 2 min read

Can kratom cause high blood pressure

Exploring the Connection Between Kratom and Blood Pressure

Kratom, a plant native to Southeast Asia, has gained popularity in recent years for its purported therapeutic effects. While some individuals utilize kratom for pain relief, anxiety reduction, and mood enhancement, concerns regarding its potential adverse effects have emerged. Among these concerns is the question of whether kratom can contribute to elevated blood pressure.

Kratom's Effects on the Cardiovascular System

Kratom's impact on the cardiovascular system is complex and multifaceted. At lower doses, kratom exhibits stimulant properties, leading to increased heart rate and blood pressure. This effect is attributed to the presence of mitragynine, the primary alkaloid in kratom. Mitragynine interacts with opioid receptors in the body, activating certain signaling pathways that influence cardiovascular function.

In contrast, higher doses of kratom may produce sedative effects, potentially lowering blood pressure. This is due to the activation of different opioid receptors that mediate vasodilation, the widening of blood vessels. Vasodilation facilitates blood flow, reducing pressure on blood vessel walls and consequently lowering blood pressure.

Studies on Kratom and Blood Pressure

While anecdotal reports suggest a link between kratom use and elevated blood pressure, scientific evidence remains limited. A 2018 study published in the journal "Clinical Pharmacology" found no significant difference in blood pressure among kratom users and non-users. However, the study's authors acknowledged the limitations of their research, including the small sample size and potential for confounding factors.

A more recent study, published in the journal "Frontiers in Pharmacology" in 2022, examined the effects of kratom on blood pressure in rats. The study found that kratom administration led to a dose-dependent increase in blood pressure. However, it is important to note that animal studies may not directly translate to human responses.

Individual Factors and Kratom's Impact

The potential effects of kratom on blood pressure may vary depending on individual factors such as age, underlying health conditions, and concurrent medications. Individuals with pre-existing hypertension or other cardiovascular issues should exercise caution when considering kratom use.

Addressing Blood Pressure Concerns

If you are concerned about kratom's potential impact on your blood pressure, it is essential to consult with a healthcare professional. They can assess your individual risk factors and provide guidance on whether kratom is appropriate for you. Additionally, regular blood pressure monitoring is recommended if you choose to use kratom.


The relationship between kratom and blood pressure requires further investigation. While some studies suggest a potential link, more robust research is needed to clarify the nature and extent of this association. Individuals with cardiovascular concerns should exercise caution when considering kratom use and seek guidance from their healthcare provider.

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